HCC Risk Calculator is the HCC risk-prediction score in patients with chronic hepatitis B. This risk calculator was designed to include simple, non-invasive, and routinely measured factors that are sex, age, serum ALT concentration, HBeAg status, and serum HBC DNA level. A 17-point risk-score was developed and validated with these clinical factors. The resulting risk score was accurate and reliable, with predicted risk correlating well with observed risk. This risk-prediction instrument could be used by a wide range of health-care professionals, from general practitioners to experienced hepatologists. It might also provide valuable insights for health authorities needing information for long-term resource planning. Another opportunity for this risk calculator is in communication of risk to patients, which could lead to better treatment acceptance and compliance in patients needing therapy.